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Use of Vitamin E and Glutamine in the Successful Treatment of Severe Veno-Occlusive Disease Following Bone Marrow Transplantation

Department of Nutrition and Surgical Metabolism, Brigham and Women's Hospital, Harvard Medical School

Angela Charlton, RD

Dana Farber Cancer Institute, Boston

Douglas W. Wilmore, MD

Department of Nutrition and Surgical Metabolism, Brigham and Women's Hospital, Harvard Medical School

Veno-occlusive disease of the liver is a common complication following the administration of conditioning regimens to patients undergoing bone marrow transplantation. Free-radical damage to the liver is believed to be the cause of the hepatic outflow occlusion, and maintenance of adequate antioxidant stores of glutathione and vitamin E may be a means of counteracting the hepatotoxicity. We report the case of a 44-year-old woman who developed severe veno-occlusive disease after bone marrow transplantation and was treated with vitamin E, the major antioxidant of the cell membrane, and glutamine, a precursor of glutathione. The administration of this therapy was associated with reversal of the clinical and biochemical signs of severe hepatic dysfunction.

Nutrition in Clinical Practice, Vol. 10, No. 1, 16-18 (1995)
DOI: 10.1177/011542659501000116


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