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Nutrition in Clinical Practice
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FDA Safety Alert: Hazards of Precipitation Associated With Parenteral Nutrition

Barbara T. Mckinnon, PHARMD, BCNSP

Pharmacy Services, Nova Factor, and Department of Clinical Pharmacy, University of Tennessee, Memphis

In April 1994, the Food and Drug Administration issued a Safety Alert regarding the hazards of precipitation associated with parenteral nutrition in response to reports of two deaths and at least two cases of respiratory distress in patients receiving three-in-one admixtures. The admixtures were thought to contain a precipitate of calcium phosphate, and patient autopsies revealed diffuse microvascular pulmonary emboli. The American Society for Parenteral and Enteral Nutrition took an active role in informing its members of the alert and responding to their concerns. Release of the alert has caused nutrition practitioners to reevaluate their compounding practices, use of filters, prescribing practices for calcium and phosphate in parenteral nutrition solutions, and use of three-in-one admixtures.

Nutrition in Clinical Practice, Vol. 11, No. 2, 59-65 (1996)
DOI: 10.1177/011542659601100259
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This article has been cited by other articles:


Home page
 JPEN J Parenter Enteral NutrHome page
A.S.P.E.N.
Safe Practices for Parenteral Nutrition Formulations
JPEN J Parenter Enteral Nutr, March 1, 1998; 22(2): 49 - 66.
[PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
A.S.P E.N.
Safe Practices for Parenteral Nutrition Formulations: National Advisory Group On Standards and Practice Guidelines for Parenteral Nutrition Approved By a.S.P.E.N. Board of Directors January 17, 1997
JPEN J Parenter Enteral Nutr, March 1, 1998; 22(2_suppl): 49 - 66.
[PDF]