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Nutrition in Clinical Practice
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Clinical Research: Is Routine Vitamin K Supplementation Required in Hospitalized Patients Receiving Parenteral Nutrition?

Donald R. Duerksen, MD

Departments of Medicine Nursing, St. Boniface General Hospital, University of Manitoba, Winnipeg, Canada

Noreen Papineau, RN, CNSN

Departments of Medicine Nursing, St. Boniface General Hospital, University of Manitoba, Winnipeg, Canada

Vitamin K is not a component of the multivitamin preparation added to parenteral nutrition solutions, and hospitalized patients receiving parenteral nutrition (PN) support are at risk of developing vitamin K deficiency. In this study, 70 consecutive patients receiving PN were followed prospectively to determine the incidence of a raised international normalized ratio (INR). Over a 3-week period, 20% of patients developed a raised INR compared with baseline. All elevations were mild, with no patients developing clinical bleeding. An alternative to routinely supplementing vitamin K is monitoring INR and supplementing those individuals with elevated coagulation parameters.

Nutrition in Clinical Practice, Vol. 15, No. 2, 81-83 (2000)
DOI: 10.1177/088453360001500205
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