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Use of B Vitamins to Reduce Homocysteine in Chronic Mesenteric Ischemia

John S. Minasi, MD, CNSP

Recent research suggests that hyperhomo-cysteinemia is a significant risk factor for thrombosis. The mechanism for this is not completely understood. However, studies have shown that high intakes of folic acid, vitamin B¹², and vitamin B⁶ can lower homocysteine levels. This case study describes a patient with a 7-year history of postprandial pain who was diagnosed with mesenteric ischemia. She was found to have moderate hyperhomocysteinemia and was subsequently treated with B vitamins. Unable to tolerate enteral nutrition, the patient was maintained on- parenteral nutrition before surgery. After resection of ischemic, strictured gut, her parenteral nutrition was discontinued and she gained weight on an oral diet. Her serum homocysteine level dropped to low-normal, therefore, vitamin B supplementation continues. Since surgery, the patient has been without symptoms of chronic ischemia.

Nutrition in Clinical Practice, Vol. 15, No. 4, 171-173 (2000)
DOI: 10.1177/088453360001500403


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