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Nutrition in Clinical Practice
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Intravenous Hyperalimentation and Cancer: A Historical Perspective

Todd W. Mattox, PharmD, BCNSP

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida

Correspondence: Correspondence and reprint requests: Todd W. Mattox, PharmD, 12902 Magnolia Drive, Tampa, FL 33612-9497. Electronic mail may be sent to mattoxtw{at}moffitt.usf.edu.

The role of total parenteral nutrition (TPN) in the supportive care of cancer patients has evolved over the past 25 to 30 years. Multiple investigations and subsequent meta-analysis review of the results of selected randomized controlled trials have been conducted in an attempt to better define the tumor-bearing patient who is most likely to respond favorably to TPN intervention. A historical perspective on the evolution of TPN in cancer patients was provided by Dr Edward Copeland in his 1986 Jonathon E. Rhoads Lecture. This classic article is summarized and additional data from more recent publications are included to provide a current perspective of the role of TPN in cancer patients.

Nutrition in Clinical Practice, Vol. 17, No. 4, 249-251 (2002)
DOI: 10.1177/0115426502017004249
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T. W. Mattox
Treatment of Unintentional Weight Loss in Patients With Cancer
Nutr Clin Pract, August 1, 2005; 20(4): 400 - 410.
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