Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more infromation

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Nutrition in Clinical Practice
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Stechmiller, J. K.
Right arrow Articles by Cowan, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stechmiller, J. K.
Right arrow Articles by Cowan, L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Invited Reviews

Arginine Supplementation and Wound Healing

Joyce K. Stechmiller, ARNP, PhD, CS
Beverly Childress, ARNP, PhD
Linda Cowan, RN, CWS

College of Nursing, University of Florida, Gainesville, Florida

Correspondence: Correspondence: Joyce K. Stechmiller, ARNP, PhD, CS, Associate Professor, University of Florida College of Nursing, Adult & Elderly Nursing, PO Box 100187, Gainesville, FL 32605. Electronic mail may be sent to Stechjk{at}nursing.ufl.edu.

Modern advances in nutritional therapies have led to the specific use of arginine supplementation for protein synthesis, cell signaling through the production of nitric oxide, and cell proliferation through its metabolism to ornithine and to polyamines. Arginine is classified as a nonessential amino acid that becomes a conditionally essential substrate in stressed adults. Arginine has been shown to enhance wound strength and collagen deposition in artificial incisional wounds in rodents and humans. A role for dietary intervention in the form of arginine supplementation has been proposed to normalize or enhance wound healing in humans. Although this hypothesis is frequently discussed, the therapeutic effect of arginine supplementation on chronic wound healing in humans is still undetermined and requires further objective evidence. Well-designed clinical trials are required to determine whether arginine supplementation is effective in enhancing healing of acute and chronic wounds in humans and how much arginine is recommended to meet metabolic needs during the phases of wound healing.

Nutrition in Clinical Practice, Vol. 20, No. 1, 52-61 (2005)
DOI: 10.1177/011542650502000152
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
G. K. Grimble
Adverse Gastrointestinal Effects of Arginine and Related Amino Acids
J. Nutr., June 1, 2007; 137(6): 1693S - 1701S.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
V. H. Castellanos, M. D. Litchford, and W. W. Campbell
Modular Protein Supplements and Their Application to Long-Term Care
Nutr Clin Pract, October 1, 2006; 21(5): 485 - 504.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
C. Thompson and M. P. Fuhrman
Nutrients and Wound Healing: Still Searching for the Magic Bullet
Nutr Clin Pract, June 1, 2005; 20(3): 331 - 347.
[Abstract] [Full Text] [PDF]