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Experimental Studies Defining -3 Fatty Acid Antiinflammatory Mechanisms and Abrogation of Tumor-Related Syndromes

Tricia A. Babcock, MS^*, Thomas Dekoj, BS^* and N. Joseph Espat, MD, MS, FACS

^* Department of Surgery and Departments of Surgery and Pharmacology, University of Illinois at Chicago

Correspondence: N. Joseph Espat, MD, MS, FACS, Associate Professor of Surgery, University of Illinois at Chicago, Department of Surgery M/C 958, 840 S. Wood St., Room 435E, Chicago, IL 60612. Electronic mail may be sent to jespat{at}uic.edu.

Clinical and experimental evidence has supported a benefit for the inclusion of fish oils (a primary source of -3 fatty acids) as a component of a normal healthy diet. Polyunsaturated -3 fatty acids have been demonstrated to be of benefit in a number of inflammation-associated disease states, including atherosclerosis, autoimmune disorders, malignancy, and sepsis. The beneficial effects of -3 fatty acids are thought to occur through the postulated antiinflammatory actions of -3 fats; however, the specific mechanism(s) of action has not been completely defined. In this review, we discuss the recent progress made in our laboratory on defining the mechanisms of -3 fatty acids activity.

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