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Experimental Studies Defining -3 Fatty Acid Antiinflammatory Mechanisms and Abrogation of Tumor-Related Syndromes
Tricia A. Babcock, MS*
Thomas Dekoj, BS*
N. Joseph Espat, MD, MS, FACS
* Department of Surgery and
Departments of Surgery and Pharmacology,
University of Illinois at Chicago
Correspondence: Correspondence: N. Joseph Espat, MD, MS, FACS, Associate Professor of Surgery,
University of Illinois at Chicago, Department of Surgery M/C 958, 840 S. Wood
St., Room 435E, Chicago, IL 60612. Electronic mail may be sent to
jespat{at}uic.edu.
Clinical and experimental evidence has supported a benefit for the
inclusion of fish oils (a primary source of -3 fatty acids) as a
component of a normal healthy diet. Polyunsaturated -3 fatty acids have
been demonstrated to be of benefit in a number of inflammation-associated
disease states, including atherosclerosis, autoimmune disorders, malignancy,
and sepsis. The beneficial effects of -3 fatty acids are thought to
occur through the postulated antiinflammatory actions of -3 fats;
however, the specific mechanism(s) of action has not been completely defined.
In this review, we discuss the recent progress made in our laboratory on
defining the mechanisms of -3 fatty acids activity.
Nutrition in Clinical Practice, Vol. 20, No. 1,
62-74 (2005)
DOI: 10.1177/011542650502000162

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[Abstract]
[Full Text]
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