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Nutrition in Clinical Practice
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Invited Reviews

Criteria for the Use of Recombinant Human Growth Hormone in Short Bowel Syndrome

Neha R. Parekh, MS, RD, LD, CNSD*,{ddagger} and Ezra Steiger, MD, FACS, CNSP*,{dagger},{ddagger}

* Intestinal Rehabilitation Program,{dagger} Nutrition Support and Vascular Access Department, and {ddagger} Department of General Surgery, Cleveland Clinic Foundation, Cleveland, Ohio

Correspondence: Neha R. Parekh, MS, RD, LD, CNSD, Intestinal Rehabilitation Program, Cleveland Clinic Foundation, 9500 Euclid Avenue, A80, Cleveland, OH 44195. Electronic mail may be sent to parekhn{at}ccf.org.

Extensive resection of the intestinal tract with resulting malabsorption is known as short bowel syndrome (SBS). Adaptation and rehabilitation of the remaining small bowel occurs spontaneously after resection and can be enhanced by diet, medications, and use of intestinal trophic factors such as recombinant human growth hormone (r-hGH). Many trials have been published on the influence of r-hGH therapy in SBS patients, with varying results. Analysis of the trials has produced a set of criteria that can be used to define the patient most likely to benefit from r-hGH therapy.

Nutrition in Clinical Practice, Vol. 20, No. 5, 503-508 (2005)
DOI: 10.1177/0115426505020005503
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