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Nutrition in Clinical Practice
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Invited Reviews

Dumping Syndrome: Pathophysiology and Treatment

Andrew Ukleja, MD

Department of Gastroenterology, Cleveland Clinic Florida, Weston, Florida

Correspondence: Correspondence: Andrew Ukleja, MD, 2950 Cleveland Clinic Blvd, Cleveland Clinic Florida, Weston, FL 33331. Electronic mail may be sent to uklejaa{at}ccf.org.

Anatomic and physiologic changes introduced by gastric surgery result in clinically significant dumping syndrome in approximately 10% of patients. Dumping is the effect of alteration in the motor functions of the stomach, including disturbances in the gastric reservoir and transporting function. Gastrointestinal hormones play an important role in dumping by mediating responses to surgical resection. Treatment options of dumping syndrome include diet, medications, and surgical revision. Poor nutrition status can be anticipated in patients who fail conservative therapy. Management of refractory dumping syndrome can be a challenge. This review highlights current knowledge about the mechanisms of dumping syndrome and available therapy.

Nutrition in Clinical Practice, Vol. 20, No. 5, 517-525 (2005)
DOI: 10.1177/0115426505020005517
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