This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Cole, S. B. Articles by Uphold, C. R. Search for Related Content PubMed PubMed Citation Articles by Cole, S. B. Articles by Uphold, C. R. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information AIDS Antioxidants Smoking Hazardous Substances DB ASCORBIC ACID SODIUM ASCORBATE Social Bookmarking                         What's this?

Oxidative Stress and Antioxidant Capacity in Smoking and Nonsmoking Men With HIV/Acquired Immunodeficiency Syndrome

Suzanne B. Cole, MS, RD^*,
Bobbi Langkamp-Henken, PhD, RD^*,
Bradley S. Bender, MD^,
Kimberly Findley, RN^,
Kelli A. Herrlinger-Garcia, BS^*,
Constance R. Uphold, PhD, ARNP-BC, FAAN^,

^* Food Science and Human Nutrition, University of Florida, Gainesville, Florida; and the Rehabilitation Outcomes Research Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida

Correspondence: Correspondence: Bobbi Langkamp-Henken, PhD, RD, Food Science and Human Nutrition, University of Florida, PO Box 110370, Gainesville, FL. Electronic mail may be sent to henken{at}ufl.edu.

Background: Past studies document decreased levels of antioxidants and selenium and increased levels of oxidative stress in people living with HIV/acquired immunodeficiency syndrome (AIDS). Cigarette smoking is another source of oxidative stress. Excessive oxidative stress can induce HIV replication, resulting in disease progression. The purpose of this study was to determine whether subjects with HIV/AIDS who smoke cigarettes have increased oxidative stress and decreased antioxidant status compared with nonsmokers with HIV/AIDS. Methods: Thirty-one men with HIV/AIDS (adhering to highly active antiretroviral therapy for the previous 3 months) were recruited during regular visits to a Veterans Affairs Medical Center Infectious Disease Clinic in a southeastern US city. Plasma was obtained from a 1-time blood draw for this comparison study. Plasma lipid peroxide (LPO) was used as a marker of oxidative stress. Indicators of antioxidant capacity included plasma glutathione peroxidase (GPx, the functional indicator of selenium status), vitamin C, and antioxidant potential (AOP). Results: Fifteen smokers and 10 nonsmokers with HIV/AIDS were enrolled. Median plasma LPO level was above the normal range of 0–1.3 µmol/L in both nonsmokers (2.5 [0–23.4] µmol/L, median [range]) and smokers (4.0 [0–47.5] µmol/L), but there was no difference between groups. Plasma GPx concentration was significantly lower in smokers (169 [118–295] µmol/min/L) compared with nonsmokers (197 [149–414] µmol/min/L). Vitamin C and AOP levels were not different between groups. Conclusions: This pilot study suggests that effects of smoking on oxidative stress are not additive, as no striking differences were observed in oxidative stress or antioxidant capacity between clinically stable smoking and nonsmoking men with HIV/AIDS.

Nutrition in Clinical Practice, Vol. 20, No. 6, 662-667 (2005)
DOI: 10.1177/0115426505020006662


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				T. L. Adair-Kirk, J. J. Atkinson, G. L. Griffin, M. A. Watson, D. G. Kelley, D. DeMello, R. M. Senior, and T. Betsuyaku Distal Airways in Mice Exposed to Cigarette Smoke: Nrf2-Regulated Genes Are Increased in Clara Cells Am. J. Respir. Cell Mol. Biol., October 1, 2008; 39(4): 400 - 411. [Abstract] [Full Text] [PDF]

				H. Vunta, F. Davis, U. D. Palempalli, D. Bhat, R. J. Arner, J. T. Thompson, D. G. Peterson, C. C. Reddy, and K. S. Prabhu The Anti-inflammatory Effects of Selenium Are Mediated through 15-Deoxy-{Delta}12,14-prostaglandin J2 in Macrophages J. Biol. Chem., June 22, 2007; 282(25): 17964 - 17973. [Abstract] [Full Text] [PDF]