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Nutrition in Clinical Practice
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Invited Review

Considerations in Fluids and Electrolytes After Traumatic Brain Injury

Denise H. Rhoney, PharmD, FCCP* and Dennis Parker, Jr, PharmD{dagger}

* Wayne State University, Eugene Applebaum College of Pharmacy & Health Sciences, Department of Pharmacy Practice, Detroit, Michigan; and {dagger} Detroit Receiving Hospital, Detroit, Michigan

Correspondence: Denise H. Rhoney, PharmD, FCCP, Associate Professor, Wayne State University, Eugene Applebaum College of Pharmacy & Health Sciences, Department of Pharmacy Practice, 259 Mack Avenue, Detroit, MI 48201. Electronic mail may be sent to drhoney{at}wayne.edu.

Appropriate fluid management of patients with traumatic brain injury (TBI) presents a challenge for many clinicians. Many of these patients may receive osmotic diuretics for the treatment of increased intracranial pressure or develop sodium disturbances, which act to alter fluid balance. However, establishment of fluid balance is extremely important for improving patient outcomes after neurologic injury. The use of hyperosmolar fluids, such as hypertonic saline, has gained significant interest because they are devoid of dehydrating properties and may have other beneficial properties for patients with TBI. Electrolyte derangements are also common after neurologic injury, with many having neurologic manifestations. In addition, the role of electrolyte abnormalities in the secondary neurologic injury cascade is being delineated and may offer a potential future therapeutic intervention.

Nutrition in Clinical Practice, Vol. 21, No. 5, 462-478 (2006)
DOI: 10.1177/0115426506021005462
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This article has been cited by other articles:


Home page
 Nutr Clin PractHome page
A. M. Cook, A. Peppard, and B. Magnuson
Nutrition Considerations in Traumatic Brain Injury
Nutr Clin Pract, December 1, 2008; 23(6): 608 - 620.
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