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Nutrition in Clinical Practice, Vol. 22, No. 1,
74-88 (2007)
DOI: 10.1177/011542650702200174
Modulation of Lipid Rafts by -3 Fatty Acids in Inflammation and Cancer: Implications for Use of Lipids During Nutrition Support
Rafat A. Siddiqui, PhD*,
Kevin A. Harvey, BS*,
Gary P. Zaloga, MD and
William Stillwell, PhD
* Methodist Research Institute, Clarian Health
Partners, Indianapolis, Indiana; Baxter Health
Care, Deerfield, Illinois; and Departments of
Medicine and Biology, Indiana University–Purdue University,
Indianapolis, Indiana
Correspondence: Rafat A. Siddiqui, PhD, Methodist Research Institute, Cellular
Biochemistry, E504D, 1800 N. Capitol Ave., Indianapolis, IN 46202. Electronic
mail may be sent to
rsiddiqu{at}clarian.org.
Current understanding of biologic membrane structure and function is
largely based on the concept of lipid rafts. Lipid rafts are composed
primarily of tightly packed, liquid-ordered
sphingolipids/cholesterol/saturated phospholipids that float in a sea of more
unsaturated and loosely packed, liquid-disordered lipids. Lipid rafts have
important clinical implications because many important membrane-signaling
proteins are located within the raft regions of the membrane, and alterations
in raft structure can alter activity of these signaling proteins. Because
rafts are lipid-based, their composition, structure, and function are
susceptible to manipulation by dietary components such as -3
polyunsaturated fatty acids and by cholesterol depletion. We review how
alteration of raft lipids affects the raft/nonraft localization and hence the
function of several proteins involved in cell signaling. We focus our
discussion of raft-signaling proteins on inflammation and cancer.

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[Abstract]
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