Nutrition in Clinical Practice

 

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Nutrition in Clinical Practice, Vol. 23, No. 1, 42-48 (2008)
DOI: 10.1177/011542650802300142

Invited Review

Inflammatory Mediators and Home Parenteral Nutrition

Mary Hise, PhD, RD, CNSD*, Charlene Compher, RD, CNSD{dagger} and John Brown, PhD{ddagger}

* Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas;{dagger} University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania; and the {ddagger} Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas

Correspondence: Mary Hise, PhD, RD, CNSD, University of Kansas Medical Center, Department of Dietetics and Nutrition, 3901 Rainbow Boulevard 4096 DELP, Mail Stop 4013, Kansas City, KS 66160-7250. Electronic mail may be sent to mhise{at}kumc.edu.

Individuals who have sustained intestinal failure due to trauma or disease are able to survive through the use of parenteral nutrition (PN). Although home PN (HPN) is a lifesaving therapy, patients may, over the long term, be at risk for liver, bone, and immune dysfunction. A limited number of human studies and a large number of animal studies suggest that there may be a chronic inflammatory condition and additionally a potentially lower T-lymphocyte immune function associated with PN administration. This article will primarily focus on a review of the limited clinical literature that examines the effect of long-term PN on the occurrence of inflammatory mediators in HPN patients, and will discuss the factors that are currently hypothesized to contribute to the potential inflammatory sequelae.


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