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Nutrition in Clinical Practice
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Invited Review

Inflammatory Mediators and Home Parenteral Nutrition

Mary Hise, PhD, RD, CNSD*
Charlene Compher, RD, CNSD{dagger}
John Brown, PhD{ddagger}

* Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, Kansas;{dagger} University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania; and the {ddagger} Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas

Correspondence: Correspondence: Mary Hise, PhD, RD, CNSD, University of Kansas Medical Center, Department of Dietetics and Nutrition, 3901 Rainbow Boulevard 4096 DELP, Mail Stop 4013, Kansas City, KS 66160-7250. Electronic mail may be sent to mhise{at}kumc.edu.

Individuals who have sustained intestinal failure due to trauma or disease are able to survive through the use of parenteral nutrition (PN). Although home PN (HPN) is a lifesaving therapy, patients may, over the long term, be at risk for liver, bone, and immune dysfunction. A limited number of human studies and a large number of animal studies suggest that there may be a chronic inflammatory condition and additionally a potentially lower T-lymphocyte immune function associated with PN administration. This article will primarily focus on a review of the limited clinical literature that examines the effect of long-term PN on the occurrence of inflammatory mediators in HPN patients, and will discuss the factors that are currently hypothesized to contribute to the potential inflammatory sequelae.

Nutrition in Clinical Practice, Vol. 23, No. 1, 42-48 (2008)
DOI: 10.1177/011542650802300142
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