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Nutrition in Clinical Practice
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Clinical Research

The Impact of Fiber Supplementation on ADMA Levels

Dana E. King, MD1
Mark DeLegge, MD2

From the 1 Department of Family Medicine and the2 Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina.

Correspondence: Address correspondence to: Dana E. King, MD, Medical University of South Carolina, Department of Family Medicine, 295 Calhoun Street, Charleston, SC 29425; e-mail: kingde{at}musc.edu.

Background: Asymmetric dimethylarginine (ADMA) is an emerging biomarker that has been associated with oxidative metabolism and increased cardiovascular risk. Little information is available regarding the effect of diet on ADMA. Methods: The authors studied 86 overweight/obese adults as part of a clinical trial of psyllium supplementation to determine whether 3 months of such supplementation would affect ADMA levels. Forty-one people in the intervention group received 14 g/day of psyllium in addition to their usual diet compared with 45 controls who followed their usual diet alone. The 2 groups were comparable at baseline in demographic characteristics and body mass index. Results: Baseline ADMA levels were elevated in this overweight/obese population compared with published reference values in healthy individuals (0.75 vs 0.50 µmol/L). The change in ADMA levels over 3 months was not different in the psyllium group compared with the control group (–.03 vs –.01 µmol/L, P = .73). Conclusions: These findings do not support a significant effect of psyllium fiber supplementation on ADMA.

Key Words: N,N-dimethylarginine • dietary psyllium • fiber • obesity

Nutrition in Clinical Practice, Vol. 24, No. 1, 80-83 (2009)
DOI: 10.1177/0884533608329229
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