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Nutrition in Clinical Practice
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Medication-Nutrient Interactions: Hypophosphatemia Associated With Sucralfate in the Intensive Care Unit

Sarah Johnston Miller, PHARMD

University of Montana School of Pharmacy, and Saint Patrick Hospital, Missoula, Montana

Jeff Simpson, BSPHARM

University of Montana School of Pharmacy, and Saint Patrick Hospital, Missoula, Montana

Clinically significant medication-nutrient interactions are of concern to the nutritional support practitioner. To emphasize the possible effect of the aluminum-containing medication sucralfate on serum phosphorus levels, patients admitted to the intensive care unit of a small private hospital were monitored for a 4-week period. Sixteen patients demonstrated low serum phosphorus levels; eight (50%) of these were receiving sucralfate. Eighteen patients had no low phosphorus levels measured; five (28%) patients in this group were receiving sucralfate. The hypophosphatemia observed in these patients was probably multifactorial; respiratory alkalosis and dextrose feeding as well as sucralfate use are consistent with hypophosphatemia.

Nutrition in Clinical Practice, Vol. 6, No. 5, 199-201 (1991)
DOI: 10.1177/0115426591006005199
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