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Nutrition in Clinical Practice
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Invited Review: The Current Role of Small-Bowel Transplantation in Intestinal Failure

Darryl T. Hiyama, MD

Department of Surgery, University of California, Los Angeles School of Medicine

Short bowel syndrome is the clinical manifestation of a fundamental reduction in the functional intestinal absorptive surface area and malabsorption. The development of total parenteral nutrition has improved the natural course of this disease. Home parenteral nutrition-related complications continue to generate significant morbidity and mortality for these patients. Small-bowel transplantation is an alternative to home parenteral nutrition. There are significant risks of graft rejection and the potential complications oflong-term immunosuppression. Small-bowel transplantation is an option, but it should be reserved for patients no longer considered candidates for continued home parenteral nutrition.

Nutrition in Clinical Practice, Vol. 8, No. 1, 5-11 (1993)
DOI: 10.1177/011542659300800105
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