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Nutrition in Clinical Practice
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Invited Review: Nutrition Support in Patients With Cancer: What Do the Data Really Show?

Samuel Klein, MD

Departments of Internal Medicine and Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston

Ronald L. Koretz, MD

Department of Internal Medicine, Olive View-UCLA Medical Center, Sylmar, California

Although more than 70 prospective randomized controlled trials have evaluated the use of nutrition support in patients with cancer, the indications for nutrition therapy in this patient population remain controversial. We reviewed the published prospective randomized controlled trials that evaluated clinically important endpoints (morbidity, mortality, and duration of hospitalization). Many trials had serious shortcomings in study design that limit the ability to draw definitive conclusions from the data. In general, the data failed to demonstrate the clinical efficacy of providing nutrition support to most patients with cancer. Therefore, the indications for using nutrition therapy should be the same as those for patients with benign disease.

Nutrition in Clinical Practice, Vol. 9, No. 3, 91-100 (1994)
DOI: 10.1177/011542659400900391
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